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KMID : 1036920150200020069
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Annals of Pediatric Endocrinology & Metabolism
2015 Volume.20 No. 2 p.69 ~ p.73
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Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus
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Kim Min-Sun
Lee Dae-Yeol
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Abstract
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Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response to the diabetic milieu. A significant reduction of serum IGF-I levels was observed in patients with type 1 diabetes mellitus (T1DM). Inversely, considerably increased serum levels of IGF-I and IGFBP-3 levels were detected in individuals with glucose intolerance including T2DM. Recently, several prospective studies indicated that baseline levels of IGF-I and IGFBPs are associated with the development of diabetes. These findings suggest that disturbances in insulin and IGF-I-IGFBP axis can affect the development of glucose intolerance including diabetes.
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KEYWORD
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Diabetes mellitus, Insulin-like growth factor I, Insulin-like growth factor binding protein 1, Insulin-like growth factor binding protein 3, Lipid metabolism
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